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Agreement assessment techniques are widely used in examining the acceptability of a new or generic process, methodology and/or formulation in areas of lab performance, instrument/assay validation or method comparisons, statistical process control, goodness-of-fit, and individual bioequivalence. Successful applications in these situations require a sound understanding of both the underlying theory and methodological advances in handling real-life problems. This book seeks to effectively blend theory and applications while presenting readers with many practical examples. For instance, in the medical device environment, it is important to know if the newly established lab can reproduce the instrument/assay results from the established but outdating lab. When there is a disagreement, it is important to differentiate the sources of disagreement. In addition to agreement coefficients, accuracy and precision coefficients are introduced and utilized to characterize these sources. This book will appeal to a broad range of statisticians, researchers, practitioners and students, in areas of biomedical devices, psychology, medical research, and others, in which agreement assessment are needed. Many practical illustrative examples will be presented throughout the book in a wide variety of situations for continuous and categorical data.
The capacity to mount stone tools in or on a handle is considered an important innovation in past human behavior. The insight to assemble two different materials (organic and inorganic) into a better functioning entity indicates the presence of the required mental capacity and technological expertise. Although the identification of stone tool use based on microscopic analysis was introduced in the 1960s, distinguishing between handheld and hafted tool use has remained a more difficult issue. This volume introduces a methodology, based on a systematic, in-depth study of prehension and hafting traces on experimental stone artifacts. The author proposes a number of distinctive macro- and microscopic wear traits for identifying handheld and hafted stone tools and for identifying the exact hafting arrangement. Included with this book is a CD-ROM that contains additional data tables and images.
Addiction Recovery Tools: A Practical Handbook presents verified recovery tools with a methodical "when and how" approach for each available tool. Including both Western and Eastern methods, the book catalogs the motivational, medical-pharmaceutical, cognitive-behavioral, psychosocial, and holistic tools accessible in a wide variety of settings and programs.
Photomultipliers are extremely sensitive light detectors that can detect single photons. In multiplying the charge produced by incident light by up to 100 million times, these devices are essential to a wide range of functions, from medical instrumentation to astronomical observations. This complete and authoritative guide will provide students, practitioners, and researchers with a deeper understanding of the operating principles of these devices. Authored by an experienced user and manufacturer of photomultipliers, this handbook gives the reader insights into photomultiplier behaviour as a means to optimize performance. Diffuse and low level light sources are best served with a photomultiplier for the detection of single photon emissions. Light detection and electron multiplication are statistical in nature and the mathematics of these processes is derived from first principles. The book covers other related topics such as scintillation counting, light guides, and large area detectors. The usually complicated subject of biasing a photomultiplier, very important for optimal performance, is reduced to a comprehensible set of calculations. All applications demand some form of electronics, the options for which are fully explored in this book.
Both by calling and conviction Father Brown knew better than most of us, that every man is dignified when he is dead. But even he felt a pang of incongruity when he was knocked up at daybreak and told that Sir Aaron Armstrong had been murdered. There was something absurd and unseemly about secret violence in connection with so entirely entertaining and popular a figure. For Sir Aaron Armstrong was entertaining to the point of being comic; and popular in such a manner as to be almost legendary.
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